Is Cannabidiol Addictive? The Scientific Truth About CBD Addiction

Main findings from clinical and animal studies aimed to evaluate the therapeutic potential of CBD for the treatment of alcohol use disorder. In one clinical study, CBD’s impact on alcohol intoxication was investigated in ten healthy volunteers, who were administered either placebo, 1 g/kg of alcohol, 200 mg of CBD, or both alcohol and CBD in a double-blind, cross-over design. Compared to placebo, the participants recieved alcohol and CBD and those consumed alcohol alone suffered significant impairments of motor and psychomotor performance and conveyed significant overestimations of time.

is cannabidiol addictive

Importantly, the restorative properties of CBD were also explored in 18 regular cannabis users (heavy and light users) enrolled in a 10 weeks open-label pragmatic trial. Authors measured baseline and post-CBD hippocampal subregions volumes by structural fMRI. CBD restored cannabis-induced anatomical disturbances in the subicular and CA1 subfields of the hippocampus (HIPP) in current cannabis users, especially in those with greater lifetime exposure (Beale et al., 2018). In the same study, CBD improved psychological symptoms (depressive and psychotic-like traits) and cognition (attentional switching, verbal learning, and memory) in dependent cannabis users (Solowij et al., 2018). Finally, future attempts should be encouraged to clarify the relationship between the ECS, glutamatergic, serotonergic, and the immune system (all systems impacted by CBD treatment) since these systems are all involved in the regulation of the rewarding properties of drugs.

CBD Products That May Contain THC

Compared to other addictive compounds like prescription pain meds and street drugs, the potential and dangers of CBD addiction are very low and uncommon. CBD doesn’t cause intoxication or a sense of euphoria like prescription pain killers or street drugs, leading many addiction experts to believe that frequent CBD use has a similar potential for abuse to a placebo pill. While the World Health Organization has issued statements on the general safety of CBD, understandably, there’s still a lot we don’t know about the possible negative effects of CBD when it comes to drug interactions and possible cannabis addiction.

is cannabidiol addictive

In another study, rats were trained to self-administer alcohol at 24h intervals for seven days and then treated with CBD. CBD diminished the stress-induced drug-seeking behavior and alcohol’s is cannabidiol addictive sedative effects and inhibited the motivation for alcohol SA. These effects of CBD persisted for up to five months, while the plasma levels of CBD were evident for only three days.

Are there any CBD withdrawal symptoms?

Allergic reactions are not common, but allergy risks may increase if you are sensitive to other foods, medications, or plant-based products. Remember that CBD is a pleiotropic medication, which means it works in many ways to help you feel better. Or it might feel like you can be more active during the day with less joint and muscle pain.

is cannabidiol addictive

In the SA model, CBD (10-40 mg/kg) dose-dependently blocked acquisition and reduced total intake of cocaine in both rats and mice (Galaj et al., 2020; Luján et al., 2020), in addition to lowering voluntary consumption and progressive-ratio breaking point in mice (Luján et al., 2018). Further, CBD shifted the cocaine dose-response curve downward and lowered the breaking point under a progressive-ratio schedule of reinforcement in rats (Galaj et al., 2020) (Table 1). In terms of METH, CBD (80 mg/kg; IP) reduced the motivation towards METH SA in rats (Hay et al., 2018).

Prolonged Use of Certain Substances

Interestingly, CBD did not induce CPP, oral SA or withdrawal-related signs, findings that suggested the lack of rewarding effects of CBD (Viudez-Martínez et al., 2019). Moreover, CBD presents an excellent safety profile supported by both animal and clinical studies (Bergamaschi et al., 2011; Iffland and Grotenhermen, 2017; Taylor et al., 2018). Proof of this is the recent marketing of the drug Epidiolex®, a 99% pure oral CBD extract for the treatment of refractory childhood epilepsies (Lennox-Gastaut and Dravet syndrome) (Sekar and Pack, 2019; Raucci et al., 2020).

  • Furthermore, the administration of CBD blocked the increase of dopamine transporter (DAT) and TH gene expressions in the VTA of mice exposed to the cocaine withdrawal (Gasparyan et al., 2020).
  • Three-month treatment with Sativex (up to 113.4 of THC/105 mg of CBD) concurrent with weekly motivational enhancement therapy and cognitive behavioral therapy reduced cannabis use with no significant increases in withdrawal in cannabis-dependent participants.
  • That said, there are some potential side effects to taking CBD, and the risks aren’t fully known.
  • Sativa (cannabis) comprises various non- psychotomimetic and non-addictive constituents that, taken in isolation, present medical opportunities and maybe more easily employed for use in medical applications (Hurd, 2017).

That’s very different from its psychoactive chemical cousin, Tetrahydrocannabinol (THC), which is all about the euphoric and mind-altering effects of the drug. Paper subject to independent expert blind peer review by minimum of two reviewers. That said, there are some potential side effects to taking CBD, and the risks aren’t fully known. It’s important to be aware of what other medications you are taking so they don’t interact with CBD. CBN is another type of cannabinoid, although not much of it is found in the cannabis plant.